The organization of the human brain develops over time, following the coordinated expression of thousands of genes. Linking the development of healthy brain organization to genes involved in mental health conditions such as autism and schizophrenia could help to...
Genetics
A cluster of genetically defined brainstem neurons involved in the production and modulation of sounds
Humans and other mammals can produce a wide range of sounds, while also modulating their volume and pitch. These sounds, also known as mammalian vocalizations, play a central role in communication between both animals of the same and of different species.
Study unveils new RNA dysregulation process that contributes to neurodegeneration
Recent neuroscience studies have consistently outlined the role of the C9ORF72 gene in the development of some neurodegenerative diseases. These studies found that mutations of this gene increase the risk of developing amyotrophic lateral sclerosis (ALS) and...
Using single-nuclei RNA sequencing to examine glial cells in peripheral nerves
The peripheral nervous system is comprised of all nerves outside of the brain and the spinal cord (i.e., the central nervous system). Peripheral nerves contain a variety of different cell types, including glial cells.
A genetically encoded sensor to measure serotonin dynamics in vivo
Serotonin (5-HT), one of the primary hormones released in the human brain, has many essential functions. For instance, serotonin is known to stabilize the mood, produce feelings of well-being, regulate sleep patterns and facilitate communication between cells.