Microglia are primary immune cells that safeguard the mammalian brain, partly by devouring or 'phagocytosing' pathogens and toxic debris. Recent genetic studies have consistently highlighted the role of microglia in the development of Alzheimer's disease (AD) and...
Neuroscience
Study hints at the promise of non-hallucinogenic LSD for treating mood disorders
Mood disorders are mental health conditions characterized by persistently dysregulated moods, such as recurring feelings of depression or euphoria. According to statistics by the National Institutes of Health, approximately 1 in 5 people in the United States will...
A wearable device that records single-neuron activity while humans are walking
New technologies can greatly advance research in various fields, including medicine and neuroscience. In recent years, for instance, engineers have created increasingly sophisticated devices to record brain activity and other biological signals with high precision.
Study unveils mechanism regulating the transmission of a protein associated with the progression of Parkinson’s disease
Proteins, long polymers comprised of smaller constituents known as amino acids, play a crucial role in the functioning of the human body. Over the course of a human's life, these "strings" of proteins fold into unique 3D structures or conformations, and this folding...
A framework characterizing the cardio-behavioral responses associated with fear and anxiety
Anxiety disorders are becoming increasingly common, with estimates suggesting that almost one in three people in the U.S. will experience high levels of anxiety at some point in their life. Anxiety is essentially a feeling of unease, worry or psychological discomfort,...
Study shows that distinct pyramidal cell types drive different patterns of cortical activity during decision-making
The outer layer of the brain, known as the cortex, is made of different types of neurons. Neuroscience studies suggest that these different neuron types have distinct functions, yet for a long time this was difficult to ascertain, due to the inability to examine and...
A neural substrate that may modulate sex differences in motivation
Psychology research conducted over the past few years suggests that males and females can preferentially engage in different decision-making strategies. The precise neural underpinnings of these reported gender differences in decision-making, however, remain unclear.
The possible effects of cinnamon on memory and learning
Cinnamon, the well-known aromatic spice that many of us use to bake cakes and cook savory dishes, is derived from the inner bark of Cinnamomum trees. These are evergreen trees found in the Himalayas and other mountain areas, as well as in rainforests and other forests...
A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of brain microglia
The protein TREM2, which in humans is encoded by the TREM2 gene, is known to play a crucial role in the growth and development of different types of immune cells, including microglia. Microglia are specialized immune cells in the central nervous system that help to...
Study sheds new light on the origins of sound-evoked activity in the mouse visual cortex
Recent studies have found that brain regions previously thought to only process a specific type of sensory stimuli, such as the visual cortex, can also be affected by other sensory stimuli. This might suggest that these brain regions are in fact multi-sensory, meaning...